Sarcoptic mange, caused by Sarcoptes scabiei, threatens Iberian ibex populations, yet some individuals recover while others succumb. Recent research reveals that the key lies in their immune response. Recovered ibexes show a strong local immune reaction in their skin, effectively activating T-cells to fight the infestation. In contrast, severely affected ibexes exhibit systemic inflammation but fail to control the disease. This study highlights the crucial role of local skin immunity in combating mange and provides valuable insights for conservation and disease management across wildlife, domestic animals, and humans. Understanding these genomic responses could reshape our fight against parasitic diseases.

More about our work here https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-024-10999-4